Desmoplastic ameloblastoma: systematic review of cases reported in the literature (2023)

The aim of this review was to integrate clinical, radiological, microscopic, and molecular data from published cases of cherubism, in addition to therapeutic approaches, to provide more concise information about the disease. An electronic search was conducted in September 2019. Selection criteria included publications with sufficient clinical, radiological, and histological information to confirm the diagnosis. A total of 260 publications with 513 cases of cherubism were included. Family history was observed in 310/458 cases (67.7%).SH3BP2Mutations were reported in 101/108 cases (93.5%) and occurred mainly at protein residues 415, 418, 419, and 420. Retrospective clinical classification was possible in 175 cases. Advanced clinical grade was associated with dental agenesis but not with other clinical, radiographic, and genetic features. Specific amino acid substitutions ofSH3BP2Mutations were not associated with the clinical grade of the disease. "Wait and see" was the most common therapeutic approach. In a small number of cases, drugs with variable responses have been used in the treatment. In conclusion, there is no clear correlation between disease genotype and phenotype, but additional information on gene expression and genomic regulation is needed to better understand cherubism.

Oral Oncology, Volume 108, 2020, Article 104804

Ameloblastoma is a rare benign human odontogenic neoplasm with a lower prevalence but a higher recurrence rate. The etiology of ameloblastoma is not fully understood, hence the implementation of curative treatments is lacking. One of the proposed models of ameloblastoma evolution is related to altering DNA damage and repair effects. A growing body of literature has linked defects in DNA damage and repair mechanisms to cancer risk and various adverse health outcomes in humans. Persistent repair defects and the evasion of these unstable genomic cells from cell death mechanisms may contribute to the accumulation of selective tumorigenic or suppressoroncogenic mutations for malignant transformation. In addition, tumor growth, progression and survival also depend on its DNA repair mechanisms, so identifying a DNA repair biomarker may be beneficial in eliminating the tumor. Understanding the connections between oral injuries and the role of different DNA repair mechanisms in the context of ameloblastoma will help build a platform for translational research. This study is a literature review of previously published research in the field of ameloblastoma in terms of DNA damage and repair effects.

Journal of Cranio-Maxillofazial Surgery, Band 48, Ausgabe 2, 2020, S. 148-155

International Journal of Oral and Maxillofacial Surgery, Band 49, Ausgabe 6, 2020, S. 822-826

The purpose of this study was to determine whether the use of a professionally produced training video for third molar extraction improves understanding and retention of general information and informed consent. A prospective cohort study of adult patients undergoing a consultation followed by third molar extraction at the University of Illinois Oral and Maxillofacial Surgery Clinic in Chicago has been completed. In the initial consultation, the subjects watched an educational video and received individual, case-specific verbal information. A written test (group 1) was then completed; a subset of subjects (Group 2) was randomly selected to complete the same study at the next pre-procedure visit. The primary predictor variable was video usage. The primary outcome variable was understanding of information about third molars, as assessed by exam results. The secondary outcome variable was information retention, which was assessed using the retest results. 100 adults (34 men, 66 women; Group 1) took the test at least once; 54 (19 men, 35 women) completed both tests (group 2). Correct answers ranged from 64% to 100% in Group 1 and from 37% to 100% in Group 2. In Group 2, any questions answered incorrectly on the first visit were answered correctly on the second visit without additional information. Patient understanding and retention of relevant preoperative information is poor despite the use of an instructional video to supplement the usual verbal consultation. These results confirm the results of previous studies and may have medico-legal implications regarding the consent process for third molar surgery.

International Journal of Oral and Maxillofacial Surgery, Band 49, Ausgabe 6, 2020, S. 693-699

The aim of this study was to evaluate the treatment outcomes of patients with curative intention after the diagnosis of salivary duct cell carcinoma (SDC) in the head and neck area and to analyze the prognostic factors and the pattern of treatment failure. 59 patients treated between March 2003 and December 2018 were included in the study. The median follow-up time was 45.5 months (range 12 to 189 months). The 5-year overall survival rate was 54.7% and the 5-year disease-free survival rate was 56.8%. Nineteen recurrences occurred during the study period: four locoregional recurrences and 15 distant metastases. During the study period, 10 patients died from disease recurrence and 5 patients died from other medical causes. In the univariate analysis, lymphovascular invasion (LVI) (P=0.031) had the most significant correlation with mortality. In multivariate Cox regression analysis, LVI showed the most significant correlation with patient survival (P= 0.027). LVI was the most important prognostic factor in terms of 5-year overall survival in patients with CDS. The development of new therapeutics is necessary to improve the survival rate of these patients with LVI.

British Journal of Oral and Maxillofacial Surgery, Band 59, Ausgabe 1, 2021, S. e1-e8

Ameloblastoma is the most common benign but locally destructive epithelial odontogenic tumor. Peripheral ameloblastoma can affect soft tissue without invasion or bone involvement. The aim of this structured review was to review the literature and guide clinical management. Three online databases were searched for relevant studies: Medline, EMBASE, and Ovid Evidence-Based Medicine, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Initially, 520 articles were identified and after exclusions were applied, 45 were included. Conservative surgical excision was the treatment of choice. There was no consensus on the extent of surgical margins required. Treatment of peripheral ameloblastoma appears to favor conservative excision with narrow margins of normal tissue. A follow-up of at least 10 years is recommended to monitor for recurrence.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 129, Issue 4, 2020, pp. 357-368

Odontogenic cysts and tumors are heterogeneous lesions arising from elements or remnants of the odontogenic apparatus. Although most of these lesions are benign and never undergo malignant transformation, rare malignant tumors can arise de novo or from benign precursors. The molecular basis of these lesions is still poorly understood. This article summarizes and discusses studies that use small, medium, and large and/or "-omics" techniques to describe the molecular features of benign and malignant odontogenic lesions and briefly discusses strategies to increase the use of "-omics" - and multi-omics techniques omic approaches or integrative analyzes in the study of these lesions. A comprehensive understanding of the molecular aspects of odontogenic lesions through large-scale approaches will allow us to refine the classification of this heterogeneous group of diseases and provide more accurate biomarkers for accurate diagnosis, prognosis and the development of molecular tools for the management of patients with these conditions.